Dose-Dependent Efficacy and Safety Toxicology of Hydroxypyridinonate Actinide Decorporation Agents in Rodents: Towards a Safe and EffectiveHuman Dosing Regimen

Two hydroxypyridinone-containing actinide decorporation agents, 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2-HOPO), are being developed for the treatment of internal actinide contamination by chelation therapy. Dose-response efficacy profiles in mice were established for the removal of intravenously injected...

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Main Authors: Bunin, Deborah I., Chang, Polly Y., Doppalapudi, Rupa S., Riccio, Edward S., An, Dahlia, Jarvis, Erin E., Kullgren, Birgitta, Abergel, Rebecca J.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633606/
https://ncbi.nlm.nih.gov/pubmed/23289385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1667/RR3115.1
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