Amplification of the structurally and functionally altered epidermal growth factor receptor gene (c-erbB) in human brain tumors.

By using Southern blot analysis, we found that in two cases of human glioblastoma multiforme, cells carried amplified c-erbB genes which bore short deletion mutations within the ligand-binding domain of the epidermal growth factor (EGF) receptor. The products of these mutated c-erbB genes were about...

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Hlavní autoři: Yamazaki, H, Fukui, Y, Ueyama, Y, Tamaoki, N, Kawamoto, T, Taniguchi, S, Shibuya, M
Médium: Artigo
Jazyk:Inglês
Vydáno: 1988
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC363345/
https://ncbi.nlm.nih.gov/pubmed/3380099
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