Hyperphosphorylation of polycystin-2 at a critical residue in disease reveals an essential role for polycystin-1-regulated dephosphorylation

Mutations in PKD1 (85%) or PKD2 (15%) account for almost all cases of autosomal dominant polycystic kidney disease (ADPKD). The ADPKD proteins, termed as polycystin-1 (PC1) and polycystin-2 (PC2), interact via their C-termini to form a receptor–ion channel complex whose function and regulation are n...

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Bibliografiska uppgifter
Huvudupphovsmän: Streets, Andrew J., Wessely, Oliver, Peters, Dorien J.M., Ong, Albert C.M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2013
Ämnen:
Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633370/
https://ncbi.nlm.nih.gov/pubmed/23390129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt031
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