X-ROS signalling is enhanced and graded by cyclic cardiomyocyte stretch

AIMS: A sustained, single stretch of a cardiomyocyte activates a transient production of reactive oxygen species by membrane-located NADPH oxidase 2 (Nox2). This NoX2-dependent ROS (X-ROS) tunes cardiac Ca(2+) signalling by reversibly sensitizing sarcoplasmic reticulum Ca(2+) release channels. In co...

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Bibliografische gegevens
Hoofdauteurs: Prosser, Benjamin L., Ward, Christopher W., Lederer, W. Jonathan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2013
Onderwerpen:
Original Articles: Spotlight on T-Tubules and Ryanodine Receptor Microdomain Signalling in Cardiac Hypertrophy and Failure
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633162/
https://ncbi.nlm.nih.gov/pubmed/23524301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvt066
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