Mechanism of Action of Efinaconazole, a Novel Triazole Antifungal Agent

The mechanism of action of efinaconazole, a new triazole antifungal, was investigated with Trichophyton mentagrophytes and Candida albicans. Efinaconazole dose-dependently decreased ergosterol production and accumulated 4,4-dimethylsterols and 4α-methylsterols at concentrations below its MICs. Efina...

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Detalhes bibliográficos
Main Authors: Tatsumi, Yoshiyuki, Nagashima, Maria, Shibanushi, Toshiyuki, Iwata, Atsushi, Kangawa, Yumi, Inui, Fumie, Siu, William J. Jo, Pillai, Radhakrishnan, Nishiyama, Yayoi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3632939/
https://ncbi.nlm.nih.gov/pubmed/23459486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02063-12
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