Pleiotrophin Gene Therapy for Peripheral Ischemia: Evaluation of Full-Length and Truncated Gene Variants

Pleiotrophin (PTN) is a growth factor with both pro-angiogenic and limited pro-tumorigenic activity. We evaluated the potential for PTN to be used for safe angiogenic gene therapy using the full length gene and a truncated gene variant lacking the domain implicated in tumorigenesis. Mouse myoblasts...

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Main Authors: Fang, Qizhi, Mok, Pamela Y., Thomas, Anila E., Haddad, Daniel J., Saini, Shereen A., Clifford, Brian T., Kapasi, Neel K., Danforth, Olivia M., Usui, Minako, Ye, Weisheng, Luu, Emmy, Sharma, Rikki, Bartel, Maya J., Pathmanabhan, Jeremy A., Ang, Andrew A. S., Sievers, Richard E., Lee, Randall J., Springer, Matthew L.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3632611/
https://ncbi.nlm.nih.gov/pubmed/23630585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061413
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