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The Innate Immune Response Transcription Factor Relish Is Necessary for Neurodegeneration in a Drosophila Model of Ataxia-Telangiectasia

Neurodegeneration is a hallmark of the human disease ataxia-telangiectasia (A-T) that is caused by mutation of the A-T mutated (ATM) gene. We have analyzed Drosophila melanogaster ATM mutants to determine the molecular mechanisms underlying neurodegeneration in A-T. Previously, we found that ATM mut...

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Hlavní autoři: Petersen, Andrew J., Katzenberger, Rebeccah J., Wassarman, David A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Genetics Society of America 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3632461/
https://ncbi.nlm.nih.gov/pubmed/23502677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.113.150854
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