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The β-catenin pathway contributes to the effects of leptin on SREBP-1c expression in rat hepatic stellate cells and liver fibrosis

BACKGROUND AND PURPOSE: Liver fibrosis is commonly associated with obesity and most obese patients develop hyperleptinaemia. The adipocytokine leptin has a unique role in the development of liver fibrosis. Activation of hepatic stellate cells (HSCs) is a key step in hepatic fibrogenesis and sterol r...

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Detalhes bibliográficos
Main Authors: Zhai, Xuguang, Yan, Kunfeng, Fan, Jiye, Niu, Minghui, Zhou, Qian, Zhou, Yan, Chen, Hongshan, Zhou, Yajun
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3632249/
https://ncbi.nlm.nih.gov/pubmed/23347184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12114
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