The length of the downstream exon and the substitution of specific sequences affect pre-mRNA splicing in vitro.
We have shown previously that truncation of the human beta-globin pre-mRNA in the second exon, 14 nucleotides downstream from the 3' splice site, leads to inhibition of splicing but not cleavage at the 5' splice site. We now show that several nonglobin sequences substituted at this site can restore...
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| Veröffentlicht in: | Mol Cell Biol |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Taylor & Francis
1988
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC363217/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3352607/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.8.2.860-866.1988 |
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