Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life.

The 11-4 p53 cDNA clone failed to transform primary rat fibroblasts when cotransfected with the ras oncogene. Two linker insertion mutations at amino acid 158 or 215 (of 390 amino acids) activated this p53 cDNA for transformation with ras. These mutant cDNAs produced a p53 protein that lacked an epi...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Finlay, C A, Hinds, P W, Tan, T H, Eliyahu, D, Oren, M, Levine, A J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1988
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC363177/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2832726/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.8.2.531-539.1988
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