Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life.

The 11-4 p53 cDNA clone failed to transform primary rat fibroblasts when cotransfected with the ras oncogene. Two linker insertion mutations at amino acid 158 or 215 (of 390 amino acids) activated this p53 cDNA for transformation with ras. These mutant cDNAs produced a p53 protein that lacked an epi...

Descrizione completa

Dettagli Bibliografici

Pubblicato in:	Mol Cell Biol
Autori principali:	Finlay, C A, Hinds, P W, Tan, T H, Eliyahu, D, Oren, M, Levine, A J
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 1988
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC363177/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2832726/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.8.2.531-539.1988
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!