Heterotypic Sam-Sam association between Odin-Sam1 and Arap3-Sam: binding affinity and structural insights

Arap3 is a phosphatidylinositol 3 kinase effector protein that plays a role as GTP-ase activator (GAP) for Arf6 and RhoA. Arap3 contains a sterile alpha motif (Sam) domain that presents high sequence homology with the Sam domain of the EphA2-receptor (EphA2-Sam); both Arap3-Sam and EphA2-Sam are abl...

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Hauptverfasser: Mercurio, Flavia A., Marasco, Daniela, Pirone, Luciano, Scognamiglio, Pasqualina L., Pedone, Emilia M., Pellecchia, Maurizio, Leone, Marilisa
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3631714/
https://ncbi.nlm.nih.gov/pubmed/23239578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201200592
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