Potent Dual Inhibitors of TORC1 and TORC2 Complexes (KU-0063794 and KU-0068650) Demonstrate In Vitro and Ex Vivo Anti-Keloid Scar Activity

Mammalian target of rapamycin (mTOR) is essential in controlling several cellular functions. This pathway is dysregulated in keloid disease (KD). KD is a common fibroproliferative dermal lesion with an ill-defined treatment strategy. KD demonstrates excessive matrix deposition, angiogenesis, and inf...

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Bibliografiske detaljer
Main Authors: Syed, Farhatullah, Sanganee, Hitesh J, Bahl, Ashwani, Bayat, Ardeshir
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2013
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3631609/
https://ncbi.nlm.nih.gov/pubmed/23303455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2012.483
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