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Peptide ligands for pro-survival protein Bfl-1 from computationally guided library screening
Pro-survival members of the Bcl-2 protein family inhibit cell death by binding short helical BH3 motifs in pro-apoptotic proteins. Mammalian pro-survival proteins Bcl-x(L), Bcl-2, Bcl-w, Mcl-1 and Bfl-1 bind with varying affinities and specificities to native BH3 motifs, engineered peptides and smal...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3631442/ https://ncbi.nlm.nih.gov/pubmed/23363053 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300679a |
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