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A novel compound, denosomin, ameliorates spinal cord injury via axonal growth associated with astrocyte-secreted vimentin

BACKGROUND AND PURPOSE: In the spinal cord injury (SCI) axon regeneration is inhibited by the glial scar, which contains reactive astrocytes that secrete inhibitory chondroitin sulphate proteoglycan (CSPG). We previously reported that a novel compound, denosomin, promotes axonal growth under degener...

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Détails bibliographiques
Auteurs principaux: Teshigawara, Kiyoshi, Kuboyama, Tomoharu, Shigyo, Michiko, Nagata, Aiko, Sugimoto, Kenji, Matsuya, Yuji, Tohda, Chihiro
Format: Artigo
Langue:Inglês
Publié: Blackwell Publishing Ltd 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3631379/
https://ncbi.nlm.nih.gov/pubmed/22978525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.02211.x
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