Inhibition of TWIST1 Leads to Activation of Oncogene-Induced Senescence in Oncogene Driven Non-Small Cell Lung Cancer

A large fraction of non-small cell lung cancers (NSCLC) are dependent on defined oncogenic driver mutations. Although targeted agents exist for EGFR- and EML4-ALK-driven NSCLC, no therapies target the most frequently found driver mutation, KRAS. Furthermore, acquired resistance to the currently targ...

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Hlavní autoři: Burns, Timothy F., Dobromilskaya, Irina, Murphy, Sara C., Gajula, Rajendra P., Thiyagarajan, Saravanan, Chatley, Sarah N.H., Aziz, Khaled, Cho, Yoon-Jae, Tran, Phuoc T., Rudin, Charles M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3631276/
https://ncbi.nlm.nih.gov/pubmed/23364532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-12-0456
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