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Chloroquine Binding Reveals Flavin Redox Switch Function of Quinone Reductase 2
Quinone reductase 2 (NQO2) is an FAD-linked enzyme and the only known human target of two antimalarial drugs, primaquine (PQ) and chloroquine (CQ). The structural differences between oxidized and reduced NQO2 and the structural basis for inhibition by PQ and CQ were investigated by x-ray crystallogr...
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| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Biochemistry and Molecular Biology
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3630856/ https://ncbi.nlm.nih.gov/pubmed/23471972 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.457002 |
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