The Overexpression of Hypomethylated miR-663 Induces Chemotherapy Resistance in Human Breast Cancer Cells by Targeting Heparin Sulfate Proteoglycan 2 (HSPG2)

MicroRNAs are involved in regulating the biology of cancer cells, but their involvement in chemoresistance is not fully understood. We found that miR-663 was up-regulated in our induced multidrug-resistant MDA-MB-231/ADM cell line and that this up-regulation was closely related to chemosensitivity....

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Hlavní autoři: Hu, Haiyan, Li, Shuqin, Cui, Xiuying, Lv, Xiaobin, Jiao, Yu, Yu, Fengyan, Yao, Herui, Song, Erwei, Chen, Yongsong, Wang, Minghui, Lin, Ling
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630848/
https://ncbi.nlm.nih.gov/pubmed/23436656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.434340
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