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Secretory Defect and Cytotoxicity: THE POTENTIAL DISEASE MECHANISMS FOR THE RETINITIS PIGMENTOSA (RP)-ASSOCIATED INTERPHOTORECEPTOR RETINOID-BINDING PROTEIN (IRBP)

Interphotoreceptor retinoid-binding protein (IRBP) secreted by photoreceptors plays a pivotal role in photoreceptor survival and function. Recently, a D1080N mutation in IRBP was found in patients with retinitis pigmentosa, a frequent cause of retinal degeneration. The molecular and cellular bases f...

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Detalhes bibliográficos
Main Authors: Li, Songhua, Yang, Zhihui, Hu, Jane, Gordon, William C., Bazan, Nicolas G., Haas, Arthur L., Bok, Dean, Jin, Minghao
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630842/
https://ncbi.nlm.nih.gov/pubmed/23486466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.418251
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