MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer

Past studies have shown that amplified insulin-like growth factor 1 (IGF1)/IGF1 receptor (IGF1-R) signalling has an important role in colorectal cancer (CRC) development, progression and resistance to treatment. In this report, we demonstrate that downregulation of microRNA-497 (miR-497) as a result...

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Autori principali: Guo, S T, Jiang, C C, Wang, G P, Li, Y P, Wang, C Y, Guo, X Y, Yang, R H, Feng, Y, Wang, F H, Tseng, H-Y, Thorne, R F, Jin, L, Zhang, X D
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2013
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630484/
https://ncbi.nlm.nih.gov/pubmed/22710713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.214
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