Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma

PURPOSE: The cancer stem cell theory postulates that tumors contain a subset of cells with stem cell properties of self-renewal, differentiation and tumor-initiation. The purpose of this study is to determine the role of Notch activity in identifying lung cancer stem cells. EXPERIMENTAL DESIGN: We i...

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Bibliographic Details
Main Authors: Hassan, Khaled A., Wang, Luo, Korkaya, Hasan, Chen, Guoan, Maillard, Ivan, Beer, David G., Kalemkerian, Gregory P., Wicha, Max S.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630232/
https://ncbi.nlm.nih.gov/pubmed/23444212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-0370
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