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Gastrointestinal Stromal Tumors, Somatic Mutations and Candidate Genetic Risk Variants

Gastrointestinal stromal tumors (GISTs) are rare but treatable soft tissue sarcomas. Nearly all GISTs have somatic mutations in either the KIT or PDGFRA gene, but there are no known inherited genetic risk factors. We assessed the relationship between KIT/PDGFRA mutations and select deletions or sing...

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Détails bibliographiques
Auteurs principaux: O'Brien, Katie M., Orlow, Irene, Antonescu, Cristina R., Ballman, Karla, McCall, Linda, DeMatteo, Ronald, Engel, Lawrence S.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630216/
https://ncbi.nlm.nih.gov/pubmed/23637977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0062119
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