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Behavioral deficits in an Angelman syndrome model: Effects of genetic background and age
Angelman syndrome (AS) is a severe neurodevelopmental disorder associated with disruption of maternally inherited UBE3A (ubiquitin protein ligase E3A) expression. At the present time, there is no effective treatment for AS. Mouse lines with loss of maternal Ube3a (Ube3a(m–/p+)) recapitulate multiple...
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3629944/ https://ncbi.nlm.nih.gov/pubmed/23295389 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbr.2012.12.052 |
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