Behavioral deficits in an Angelman syndrome model: Effects of genetic background and age

Angelman syndrome (AS) is a severe neurodevelopmental disorder associated with disruption of maternally inherited UBE3A (ubiquitin protein ligase E3A) expression. At the present time, there is no effective treatment for AS. Mouse lines with loss of maternal Ube3a (Ube3a(m–/p+)) recapitulate multiple...

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Main Authors: Huang, Hsien-Sung, Burns, Andrew J., Nonneman, Randal J., Baker, Lorinda K., Riddick, Natallia V., Nikolova, Viktoriya D., Riday, Thorfinn T., Yashiro, Koji, Philpot, Benjamin D., Moy, Sheryl S.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3629944/
https://ncbi.nlm.nih.gov/pubmed/23295389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbr.2012.12.052
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