Silibinin Synergizes with Histone Deacetylase and DNA Methyltransferase Inhibitors in Upregulating E-cadherin Expression Together with Inhibition of Migration and Invasion of Human Non-small Cell Lung Cancer Cells

Aggressive cancers in the epithelial-to-mesenchymal transition (EMT) phase are characterized by loss of cell adhesion, repression of E-cadherin, and increased cell mobility. Non-small cell lung cancer (NSCLC) differs in basal level of E-cadherin; predominantly exhibiting silenced expression due to e...

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Autores principales: Mateen, Samiha, Raina, Komal, Agarwal, Chapla, Chan, Daniel, Agarwal, Rajesh
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2013
Materias:
Drug Discovery and Translational Medicine
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3629797/
https://ncbi.nlm.nih.gov/pubmed/23461975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.113.203471
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