Early Vessel Destabilization Mediated by Angiopoietin-2 and Subsequent Vessel Maturation via Angiopoietin-1 Induce Functional Neovasculature after Ischemia

BACKGROUND: We assessed whether Angiopoietin-2 (Ang2), a Tie2 ligand and partial antagonist of Angiopoietin-1 (Ang1), is required for early vessel destabilization during postischemic angiogenesis, when combined with vascular growth factors. METHODS: In vitro, matrigel co-cultures assessed endothelia...

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Главные авторы: Qin, Di, Trenkwalder, Teresa, Lee, Seungmin, Chillo, Omary, Deindl, Elisabeth, Kupatt, Christian, Hinkel, Rabea
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2013
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3628915/
https://ncbi.nlm.nih.gov/pubmed/23613948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061831
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