Pituitary Adenylate Cyclase Activating Peptide Deficient Mice Exhibit Impaired Thymic and Extrathymic Regulatory T Cell Proliferation during EAE

We have shown that mice deficient in pituitary adenylate cyclase-activating polypeptide (PACAP, gene name ADCYAP1) manifest enhanced sensitivity to experimental autoimmune encephalomyelitis (EAE), supporting the anti-inflammatory actions described for this neuropeptide. In addition to an increased p...

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Detalhes bibliográficos
Main Authors: Tan, Yossan-Var, Abad, Catalina, Wang, Yuqi, Lopez, Robert, Waschek, James A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3628797/
https://ncbi.nlm.nih.gov/pubmed/23613811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061200
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