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Measurement of 3-hydroxyisovaleric acid in urine from marginally biotin-deficient humans by UPLC-MS/MS

Measurement of 3-hydroxyisovaleric acid (3HIA) in human urine has been shown to be a useful indicator of biotin status for a variety of clinical situations, including pregnancy. The work described herein presents a novel UPLC-MS/MS method for accurate and precise quantitation of urinary 3HIA. This m...

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Detalhes bibliográficos
Main Authors: Horvath, Thomas D., Matthews, Nell I., Stratton, Shawna L., Mock, Donald M., Boysen, Gunnar
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3628633/
https://ncbi.nlm.nih.gov/pubmed/21892638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00216-011-5356-x
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