Cooperative Heparin-Mediated Oligomerization of Fibroblast Growth Factor-1 (FGF1) Precedes Recruitment of FGFR2 to Ternary Complexes

Fibroblast growth factors (FGFs) utilize cell surface heparan sulfate as a coreceptor in the assembly of signaling complexes with FGF-receptors on the plasma membrane. Here we undertake a complete thermodynamic characterization of the assembly of the FGF signaling complex using isothermal titration...

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Detalhes bibliográficos
Main Authors: Brown, Alan, Robinson, Christopher J., Gallagher, John T., Blundell, Tom L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2013
Assuntos:
Proteins and Nucleic Acids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3628569/
https://ncbi.nlm.nih.gov/pubmed/23601319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.02.051
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