Differential gene expression between skin and cervix induced by the E7 oncoprotein in a transgenic mouse model

HPV16 E7 oncoprotein expression in K14E7 transgenic mice induces cervical cancer after 6 months of treatment with the co-carcinogen 17β-estradiol. In untreated mice, E7 also induces skin tumors late in life albeit at low penetrance. These findings indicate that E7 alters cellular functions in cervix...

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Main Authors:	Ibarra Sierra, E, Díaz Chávez, J, Cortés-Malagón, EM, Uribe-Figueroa, L, Hidalgo-Miranda, A, Lambert, PF, Gariglio, P
Format:	Artigo
Sprog:	Inglês
Udgivet:	2012
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3628553/ https://ncbi.nlm.nih.gov/pubmed/22980503 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2012.08.024
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Differential gene expression between skin and cervix induced by the E7 oncoprotein in a transgenic mouse model

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