Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism

The insulin/insulin-like growth factor-1 signalling (IIS) pathway regulates cellular and organismal metabolism and controls the rate of aging. Gain-of-function mutations in p110α, the principal mammalian IIS-responsive isoform of PI 3-kinase (PI3K), promote cancer. In contrast, loss-of-function muta...

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Main Authors: Foukas, Lazaros C, Bilanges, Benoit, Bettedi, Lucia, Pearce, Wayne, Ali, Khaled, Sancho, Sara, Withers, Dominic J, Vanhaesebroeck, Bart
Formato: Artigo
Idioma:Inglês
Publicado: WILEY-VCH Verlag 2013
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3628103/
https://ncbi.nlm.nih.gov/pubmed/23483710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201201953
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