Ambra1 knockdown in zebrafish leads to incomplete development due to severe defects in organogenesis

AMBRA1 is a positive regulator of the BECN1-dependent program of autophagy recently identified in mouse. In this study, we cloned the full-length cDNAs of ambra1a and ambra1b zebrafish paralogous genes. As in mouse, both Ambra1 proteins contain the characteristic WD40 repeat region. The transcripts...

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Detalhes bibliográficos
Main Authors: Benato, Francesca, Skobo, Tatjana, Gioacchini, Giorgia, Moro, Isabella, Ciccosanti, Fabiola, Piacentini, Mauro, Fimia, Gian Maria, Carnevali, Oliana, Valle, Luisa Dalla
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
Assuntos:
Basic Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3627665/
https://ncbi.nlm.nih.gov/pubmed/23348054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.23278
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