TCDD Inhibition of Canonical Wnt Signaling Disrupts Prostatic Bud Formation in Mouse Urogenital Sinus

In mice, in utero exposure to 2,3,7,8-tetrachlorodibenzo-p- dioxin (TCDD) reduces the number of dorsolateral prostatic buds resulting in a smaller dorsolateral prostate and prevents formation of ventral buds culminating in ventral prostate agenesis. The genes and signaling pathways affected by TCDD...

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Bibliographic Details
Main Authors: Branam, Amanda M., Davis, Nicole M., Moore, Robert W., Schneider, Andrew J., Vezina, Chad M., Peterson, Richard E.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3627553/
https://ncbi.nlm.nih.gov/pubmed/23429912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kft027
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