The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence

Here, we show that a small-molecule activator of telomerase (TA-65) purified from the root of Astragalus membranaceus is capable of increasing average telomere length and decreasing the percentage of critically short telomeres and of DNA damage in haploinsufficient mouse embryonic fibroblasts (MEFs)...

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Bibliografiske detaljer
Main Authors: de Jesus, Bruno Bernardes, Schneeberger, Kerstin, Vera, Elsa, Tejera, Agueda, Harley, Calvin B., Blasco, Maria A.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3627294/
https://ncbi.nlm.nih.gov/pubmed/21426483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2011.00700.x
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