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Hormonal regulation of phosphoenolpyruvate carboxykinase gene expression is mediated through modulation of an already disrupted chromatin structure.

We used indirect end labeling to identify a series of five hypersensitive (HS) sites in the phosphoenolpyruvate carboxykinase (PEPCK) gene in H4IIE rat hepatoma cells. These sites were found at -4800 base pairs (bp) (site A), at -1300 bp (site B), over a broad domain between -400 and -30 bp (site C)...

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Udgivet i:Mol Cell Biol
Principais autores: Ip, Y T, Granner, D K, Chalkley, R
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1989
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC362721/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2657389/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.9.3.1289-1297.1989
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