Phase I study of OM-174, a lipid A analogue, with assessment of immunological response, in patients with refractory solid tumors

BACKGROUND: Lipids A, the lipophilic partial structure of lipopolysaccharides, induce regression of several tumor types in animal models. Rather than exerting direct cytotoxic effect, these compounds trigger the immune system which in turn stimulates secretion of cytokines, and activates the inducib...

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Detalhes bibliográficos
Main Authors: Isambert, Nicolas, Fumoleau, Pierre, Paul, Catherine, Ferrand, Christophe, Zanetta, Sylvie, Bauer, Jacques, Ragot, Kevin, Lizard, Gérard, Jeannin, Jean-François, Bardou, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3626800/
https://ncbi.nlm.nih.gov/pubmed/23547558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-172
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