Beneficial Effects of Trypsin Inhibitors Derived from a Spider Venom Peptide in L-Arginine-Induced Severe Acute Pancreatitis in Mice

HWTI is a 55-residue protein isolated from the venom of the spider Ornithoctonus huwena. It is a potent trypsin inhibitor and a moderate voltage-gated potassium channel blocker. Here, we designed and expressed two HWTI mutants, HWTI-mut1 and HWTI-mut2, in which the potassium channel inhibitory activ...

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Detalhes bibliográficos
Main Authors: Ning, Weiwen, Wang, Yongjun, Zhang, Fan, Wang, Hengyun, Wang, Fan, Wang, Xiaojuan, Tang, Huaxin, Liang, Songping, Shi, Xiaoliu, Liu, Zhonghua
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3626702/
https://ncbi.nlm.nih.gov/pubmed/23613780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061049
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