Targeted Overexpression of TGF-α in the Corneal Epithelium of Adult Transgenic Mice Induces Changes in Anterior Segment Morphology and Activates Noncanonical Wnt Signaling

PURPOSE. Transforming growth factor-alpha (TGF-α) transduces its signal through the epidermal growth factor receptor and is essential for corneal epithelial homeostasis. Previous studies have demonstrated that overexpression of TGF-α in the developing eye leads to anterior segment dysgenesis. Howeve...

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Autori principali: Yuan, Yong, Yeh, Lung-Kun, Liu, Hongshan, Yamanaka, Osamu, Hardie, William D., Kao, Winston W.-Y., Liu, Chia-Yang
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Association for Research in Vision and Ophthalmology 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3626521/
https://ncbi.nlm.nih.gov/pubmed/23412089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.12-11477
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