Aptamer-Crosslinked Microbubbles: Smart Contrast Agents for Thrombin-Activated Ultrasound Imaging

Thrombosis, or malignant blood clotting, is associated with numerous cardiovascular diseases and cancers. This report describes a microbubble contrast agent that produces ultrasound harmonic signal only when exposed to elevated thrombin levels. Silenced initially, microbubbles activated in the prese...

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Bibliographic Details
Main Authors: Nakatsuka, Matthew A., Mattrey, Robert F., Esener, Sadik C., Cha, Jennifer N., Goodwin, Andrew P.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3626403/
https://ncbi.nlm.nih.gov/pubmed/22941789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adma.201201484
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