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Mutagenesis of the rat insulin II 5'-flanking region defines sequences important for expression in HIT cells.

To define the cis-acting elements important for rat insulin II gene expression, we analyzed the effects of 5' deletions and linker-scanning mutations on the expression of a rat insulin II reporter gene in an insulinoma cell line (HIT). The reporter gene contained 448 base pairs of 5'-flank...

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Bibliographic Details
Published in:Mol Cell Biol
Main Authors: Crowe, D T, Tsai, M J
Format: Artigo
Language:Inglês
Published: Taylor & Francis 1989
Subjects:
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC362598/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2657405/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.9.4.1784
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