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Complementation of a methotrexate uptake defect in Chinese hamster ovary cells by DNA-mediated gene transfer.

A methotrexate-resistant Chinese hamster ovary cell line deficient in methotrexate uptake has been complemented to methotrexate sensitivity by transfection with DNA isolated from either wild-type Chinese hamster ovary or human G2 cells. Primary and secondary transfectants regained the ability to tak...

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Bibliographic Details
Published in:Mol Cell Biol
Main Authors: Underhill, T M, Flintoff, W F
Format: Artigo
Language:Inglês
Published: Taylor & Francis 1989
Subjects:
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC362594/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2725523/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.9.4.1754-1758.1989
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