Transient treatment with epigenetic modifiers yields stable neuroblastoma stem cells resembling aggressive large-cell neuroblastomas

Cancer stem cells (CSCs) are plastic in nature, a characteristic that hampers cancer therapeutics. Neuroblastoma (NB) is a pediatric tumor of neural crest origin, and half of the cases are highly aggressive. By treating NB cell lines [SKNAS, SKNBE(2)C, CHP134, and SY5Y] with epigenetic modifiers for...

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Detalhes bibliográficos
Principais autores: Ikegaki, Naohiko, Shimada, Hiroyuki, Fox, Autumn M., Regan, Paul L., Jacobs, Joshua R., Hicks, Sakeenah L., Rappaport, Eric F., Tang, Xao X.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625318/
https://ncbi.nlm.nih.gov/pubmed/23479628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118262110
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