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In vitro and in vivo delivery of genes and proteins using the bacteriophage T4 DNA packaging machine

The bacteriophage T4 DNA packaging machine consists of a molecular motor assembled at the portal vertex of an icosahedral head. The ATP-powered motor packages the 56-µm-long, 170-kb viral genome into 120 nm × 86 nm head to near crystalline density. We engineered this machine to deliver genes and pro...

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Detalhes bibliográficos
Main Authors: Tao, Pan, Mahalingam, Marthandan, Marasa, Bernard S., Zhang, Zhihong, Chopra, Ashok K., Rao, Venigalla B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625312/
https://ncbi.nlm.nih.gov/pubmed/23530211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1300867110
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