LSD2/KDM1B and Its Cofactor NPAC/GLYR1 Endow a Structural and Molecular Model for Regulation of H3K4 Demethylation

Dynamic regulation of histone methylation represents a fundamental epigenetic mechanism underlying eukaryotic gene regulation, yet little is known about how the catalytic activities of histone demethylases are regulated. Here, we identify and characterize NPAC/GLYR1 as an LSD2/KDM1b-specific cofacto...

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Main Authors: Fang, Rui, Chen, Fei, Dong, Zhenghong, Hu, Di, Barbera, Andrew J., Clark, Erin A., Fang, Jian, Yang, Ying, Mei, Pinchao, Rutenberg, Michael, Li, Ze, Zhang, Ying, Xu, Youwei, Yang, Huirong, Wang, Ping, Simon, Matthew D., Zhou, Qiongjie, Li, Jing, Marynick, Mark P., Li, Xiaotian, Lu, Haojie, Kaiser, Ursula B., Kingston, Robert E., Xu, Yanhui, Shi, Yujiang Geno
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625064/
https://ncbi.nlm.nih.gov/pubmed/23260659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.11.019
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