Transcriptional mapping of the amplified region encoding the dihydrofolate reductase-thymidylate synthase of Leishmania major reveals a high density of transcripts, including overlapping and antisense RNAs.

We have examined the transcriptional organization of the R region of the protozoan parasite Leishmania major. This region encodes the bifunctional enzyme dihydrofolate reductase-thymidylate synthase (DHFR-TS) and is frequently amplified as a 30-kilobase (kb) extrachromosomal circular DNA in methotre...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Kapler, G M, Beverley, S M
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1989
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC362458/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2476667/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.9.9.3959-3972.1989
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