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The tRNA Thiolation Pathway Modulates the Intracellular Redox State in Escherichia coli
We have performed a screening of hydroxyurea (HU)-sensitive mutants using a single-gene-deletion mutant collection in Escherichia coli K-12. HU inhibits ribonucleotide reductase (RNR), an enzyme that catalyzes the formation of deoxyribonucleotides. Unexpectedly, seven of the mutants lacked genes tha...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Microbiology
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3624572/ https://ncbi.nlm.nih.gov/pubmed/23457245 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.02180-12 |
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