Trivalent Live Attenuated Influenza-Simian Immunodeficiency Virus Vaccines: Efficacy and Evolution of Cytotoxic T Lymphocyte Escape in Macaques

There is an urgent need for a human immunodeficiency virus (HIV) vaccine that induces robust mucosal immunity. CD8(+) cytotoxic T lymphocytes (CTLs) apply substantial antiviral pressure, but CTLs to individual epitopes select for immune escape variants in both HIV in humans and SIV in macaques. Indu...

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Hauptverfasser: Reece, Jeanette C., Alcantara, Sheilajen, Gooneratne, Shayarana, Jegaskanda, Sinthujan, Amaresena, Thakshila, Fernandez, Caroline S., Laurie, Karen, Hurt, Aeron, O'Connor, Shelby L., Harris, Max, Petravic, Janka, Martyushev, Alexey, Grimm, Andrew, Davenport, Miles P., Stambas, John, De Rose, Robert, Kent, Stephen J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2013
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624373/
https://ncbi.nlm.nih.gov/pubmed/23345519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02645-12
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