Trivalent Live Attenuated Influenza-Simian Immunodeficiency Virus Vaccines: Efficacy and Evolution of Cytotoxic T Lymphocyte Escape in Macaques

There is an urgent need for a human immunodeficiency virus (HIV) vaccine that induces robust mucosal immunity. CD8(+) cytotoxic T lymphocytes (CTLs) apply substantial antiviral pressure, but CTLs to individual epitopes select for immune escape variants in both HIV in humans and SIV in macaques. Indu...

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Main Authors: Reece, Jeanette C., Alcantara, Sheilajen, Gooneratne, Shayarana, Jegaskanda, Sinthujan, Amaresena, Thakshila, Fernandez, Caroline S., Laurie, Karen, Hurt, Aeron, O'Connor, Shelby L., Harris, Max, Petravic, Janka, Martyushev, Alexey, Grimm, Andrew, Davenport, Miles P., Stambas, John, De Rose, Robert, Kent, Stephen J.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2013
נושאים:
Vaccines and Antiviral Agents
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624373/
https://ncbi.nlm.nih.gov/pubmed/23345519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02645-12
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