Synergistic Effect of the PDZ and p85β-Binding Domains of the NS1 Protein on Virulence of an Avian H5N1 Influenza A Virus

The influenza A virus NS1 protein affects virulence through several mechanisms, including the host's innate immune response and various signaling pathways. Highly pathogenic avian influenza (HPAI) viruses of the H5N1 subtype continue to evolve through reassortment and mutations. Our recent phyl...

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Detalhes bibliográficos
Main Authors: Fan, Shufang, Macken, Catherine A., Li, Chengjun, Ozawa, Makoto, Goto, Hideo, Iswahyudi, N. F. N., Nidom, Chairul A., Chen, Hualan, Neumann, Gabriele, Kawaoka, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624326/
https://ncbi.nlm.nih.gov/pubmed/23408626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02608-12
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