Structural Characterization of H-1 Parvovirus: Comparison of Infectious Virions to Empty Capsids

The structure of single-stranded DNA (ssDNA) packaging H-1 parvovirus (H-1PV), which is being developed as an antitumor gene delivery vector, has been determined for wild-type (wt) virions and noninfectious (empty) capsids to 2.7- and 3.2-Å resolution, respectively, using X-ray crystallography. The...

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Detalhes bibliográficos
Main Authors: Halder, Sujata, Nam, Hyun-Joo, Govindasamy, Lakshmanan, Vogel, Michèle, Dinsart, Christiane, Salomé, Nathalie, McKenna, Robert, Agbandje-McKenna, Mavis
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Structure and Assembly
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624314/
https://ncbi.nlm.nih.gov/pubmed/23449783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03416-12
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