MSK1 and MSK2 Inhibit Lipopolysaccharide-Induced Prostaglandin Production via an Interleukin-10 Feedback Loop

Prostaglandin production is catalyzed by cyclooxygenase 2 (cox-2). We demonstrate here that MSK1 and MSK2 (MSK1/2) can exert control on the induction of cox-2 mRNA by Toll-like receptor (TLR) agonists. In the initial phase of cox-2 induction, MSK1/2 knockout macrophages confirmed a role for MSK in t...

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Main Authors: MacKenzie, Kirsty F., Van Den Bosch, Mirjam W. M., Naqvi, Shaista, Elcombe, Suzanne E., McGuire, Victoria A., Reith, Alastair D., Blackshear, Perry J., Dean, Jonathan L. E., Arthur, J. Simon C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624268/
https://ncbi.nlm.nih.gov/pubmed/23382072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01690-12
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