Androgens with activity at estrogen receptor beta have anxiolytic and cognitive-enhancing effects in male rats and mice

Testosterone (T) and its metabolites may underlie some beneficial effects for anxiety and cognition, but the mechanisms for these effects are unclear. T is reduced to dihydrotestosterone (DHT), which can be converted to 5α-androstane,3α,17β-diol (3α-diol) and/or 5α-androstane-3β,17β-diol (3β-diol)....

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Bibliographic Details
Main Authors: Frye, Cheryl A., Koonce, Carolyn J., Edinger, Kassandra L., Osborne, Danielle M., Walf, Alicia A.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3623974/
https://ncbi.nlm.nih.gov/pubmed/18775724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yhbeh.2008.07.013
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