A Non-Synonymous Coding Variant (L616F) in the TLR5 Gene Is Potentially Associated with Crohn's Disease and Influences Responses to Bacterial Flagellin

BACKGROUND AND OBJECTIVES: Although numerous studies have implicated TLR5, or its ligands, bacterial flagellins, in the pathogenesis of Crohn's disease (CD), genome-wide association studies (GWAS) have not reported associations with the TLR5 gene. We aimed to examine potential CD-associated TLR...

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Autors principals: Sheridan, Jared, Mack, David R., Amre, Devendra K., Israel, David M., Cherkasov, Artem, Li, Huifang, Grimard, Guy, Steiner, Theodore S.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3623901/
https://ncbi.nlm.nih.gov/pubmed/23593463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061326
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